The Arizona Gray Squirrel is essentially a silent animal. Its only vocalizations are chucking and barking alarm calls, only when safely perched in a tree. The Arizona Gray Squirrel is generally not afraid of humans or dogs, but it will vocalize warnings if it detects the presence of cats, spotted skunks and snakes. When frightened, it usually runs and climbs trees to avoid the threat. But it will also remain completely still for long periods of time to avoid detection. An important strategy for its survival is to protect the nesting habitat, ensuring access to resources while protecting it from predators.

The Arizona Gray Squirrel is active during the day and is most active in the early morning. It often runs on the ground and jumps from branch to branch in trees. Normally, 1-2 squirrels are usually active together but will migrate in groups when food is extremely scarce. It builds nests in trees or just uses tree caves to live in, and has the habit of storing food for the winter. It changes its fur every spring and autumn. Besides, they don’t hibernate.

Depending on its feeding habits and the time of year, the Arizona Gray Squirrel may be secretive or easily observed. During the breeding season, when females are pregnant or nursing young, Arizona Gray Squirrels are hard to locate. Interestingly, the breeding activity of them is correlated with the blooming of flowers. The nutrition and vitamins inside help sustain the energy demands required for reproduction. Estrus occurs in females in April and early May. Mating chases also occur during the time, with several males pursuing a single female. Not all females breed each year. Breeding season runs from April to May, and the litter size ranges from two to four offspring.

Though lacking sufficient population data, it is safe to say that Arizona Gray Squirrels are rare. They are officially considered a threatened species in Mexico. In Arizona, they will be considered for federal listing as threatened or endangered.